Zerodol: Uses And Side Effects Of A Potent Pain Reliever

Written by , BSc, Professional Certificate in Food, Nutrition and Health Ravi Teja Tadimalla BSc, Professional Certificate in Food, Nutrition and Health Experience: 8 years

Zerodol is a non-steroidal anti-inflammatory drug (NSAID). It helps relieve pain in conditions like arthritis and spondylitis. It works by blocking the effect of cyclo-oxygenase enzymes (COX), which produce prostaglandins that cause pain and inflammation.

Zerodol can help you in a number of ways. In this post, we will look at all of them in detail.

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What Is Zerodol Composed Of?

Zerodol contains aceclofenac, which gives it the properties of an NSAID. Studies have shown that aceclofenac helps manage inflammatory pain. It also happens to be one of the few pain relievers that carry a low risk of causing gastrointestinal side effects (1).

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Zerodol can help you in a number of ways. Scroll down to find out how and what they are.

How Does Zerodol Help You?

1. Eases Rheumatoid Arthritis Pain

According to a UK study, oral administration of aceclofenac at 100 mg twice daily resulted in significant improvement in patients with rheumatoid arthritis (2). The compound had reduced the duration of morning stiffness and even joint swelling. Compared to the placebo patients, those who had taken aceclofenac showed better grip strength.

In another study, the aceclofenac in Zerodol emerged the winner when its efficacy was compared with ketoprofen, another commonly used NSAID. More number of patients administered with ketoprofen had abandoned the study due to the inefficacy of the drug and adverse effects as compared to aceclofenac (3).

2. Helps Treat Osteoarthritis

When compared with diclofenac, a common NSAID used for osteoarthritis pain, aceclofenac was found to have better effects. Patients with osteoarthritis found better respite with the administration of aceclofenac (4).

3. Aids Treatment Of Ankylosing Spondylitis

Ankylosing spondylitis is inflammatory arthritis that affects the spine and large joints. The condition is more common in men. The symptoms usually appear in early adulthood – one of them being reduced spinal flexibility.

Studies show how the aceclofenac in Zerodol helps in the treatment of this condition. Aceclofenac was found to be as effective as tenoxicam, a popular medication, in the treatment of ankylosing spondylitis (5).

4. Can Relieve Toothache

The efficacy of aceclofenac in Zerodol as an analgesic for dental pain has been well studied. The potent anti-inflammatory properties of aceclofenac can help control various forms of dental pain (6).

When compared to diclofenac, aceclofenac proved to have better pain-relieving properties and fewer side effects (7). This suggests the superior efficacy of aceclofenac when it comes to treating toothache.

5. Can Treat Headache

Can Treat Headache
Image: Shutterstock

A combination medication containing aceclofenac was found to improve symptoms in patients with migraine (8). However, we need more studies to establish that Zerodol could be the ideal drug for treating headache. Hence, we suggest you talk to your doctor in this regard.

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That was the good part. But like any drug, Zerodol can have some side effects as well.

What Are The Side Effects Of Zerodol?

Following are the most common side effects of Zerodol:

  • Constipation
  • Stomach pain
  • Diarrhea
  • Nausea and vomiting
  • Skin rashes

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It may not be possible to cure ailments like arthritis. But they can be managed pretty well. Zerodol is one of the drugs that can help you do so. Consult your doctor and get on the medication today. Also, ensure you maintain a balanced diet and regular physical activity.

Tell us how this post has helped you by leaving a comment in the box below.

Frequently Asked Questions

Can Zerodol be taken during pregnancy or breastfeeding?

No. The medication is not considered suitable during pregnancy or breastfeeding. Please check with your doctor too.

Can you take Zerodol with alcohol?

No. Taking the medication with alcohol can increase the risk of side effects.

What is the dosage of Zerodol?

The usual dosage is a 100 mg tablet, twice daily – once in the morning, and once in the evening. You can take it with or after food. But all of this depends on your specific health condition. Hence, do as directed by your doctor.

What are the substitutes for Zerodol?

Some of the popular substitutes for Zerodol include Movace 100 mg, Aceroc 100 mg, Movexx 100 mg, and Mahanac 100 mg.


  1. Aceclofenac in the management of inflammatory…” Expert Opinion on Pharmacotherapy, US National Library of Medicine.
  2. Aceclofenac in rheumatoid arthritis…” Clinical Rheumatology, US National Library of Medicine.
  3. Aceclofenac in comparison to ketoprofen in the...” Rheumatology International, US National Library of Medicine.
  4. Efficacy and safety of aceclofenac in the treatment of…” Current Medical Research and Opinion, US National Library of Medicine.
  5. Aceclofenac is as safe and effective as…” The Journal of Rheumatology, US National Library of Medicine.
  6. Aceclofenac: a reappraisal of its use in the…” Drugs, US National Library of Medicine.
  7. Efficacy of aceclofenac and diclofenac sodium…” Journal of Pharmacology & Pharmacotherapeutics, US National Library of Medicine.
  8. Almotriptan and its combination with aceclofenac…” Cephalalgia: An International Journal of Headache, US National Library of Medicine.
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Ravi Teja Tadimalla

Ravi Teja TadimallaSenior Editor

Ravi Teja Tadimalla is a senior editor and a published author. He has been in the digital media field for over eight years. He graduated from SRM University, Chennai, and has a Professional Certificate in Food, Nutrition & Research from Wageningen University. He has written over 300 articles about ingredients and their benefits for the skin, hair, and health. full bio